The San Croce sesteri is perhaps one of the least known of the districts in Venice. However it should not be overlooked by an astute traveler to Venice. This is because in this district are many fine restaurants and shops that are not as frequented by tourists as in other districts. What does this mean to you? It means a more real Venice experience and a ultimately less expensive one as well. If you want to make each dollar count then be sure to explore this neighborhood on your stay.
Since this is a district not frequented by many tourists you are probably thinking that there is not much to see here. Well that would be a false assumption as there are many places to see. The Ca Pesaro is off the Grand Canal and is home to the modern art museum. This is by far one of the most important art galleries in the whole of Italy and contains works from many countries and not just Italy. Secondly there is the Fondaco dei Turchi which has one of the most beautiful exteriors in the whole of Venice and was once a trading warehouse. At this moment the building is used to house the natural history museum of Venice.
This district is one of the best for nightlife in the city. If you are young and hip I am sure you will want to check out Baffo’s bar in Campo Sant Agostin. For pizza in the area I would check out Ae Oche as this place makes over 90 varieties of pizza that I am sure is bound to please at least someone in your group. For a more picturesque view while eating I would go down to Trattoria al Ponte which is very near to the bridge and has a few outdoor tables. Finally if you want a unique experience that you will not find anywhere else be sure to check out La Zucca which has a reputation for a innovative use of its vegetables.
It is hard to find a truly unique experience when visiting a tourist trap that is Venice Italy. However this neighborhood is sure to be a highlight to the savvy traveler and not the average tourist. I would however make sure that you are somewhat conversant in the Italian language as I am sure your experience will be enhanced.